An analysis of the hiv virus and the causes for aids

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An analysis of the hiv virus and the causes for aids

Abstract Background We examined specific causes of mortality in human immunodeficiency virus type 1 HIV-1 —infected patients who initiated antiretroviral therapy ART in Europe and North America from throughand we quantified associations of prognostic factors with cause-specific mortality.

Methods We retrospectively classified all deaths among 39, patients enrolled in 13 HIV-1 cohortsperson years of follow-up into the categories specified in the Cause of Death CoDe project protocol.


Among these, deaths Rates of each cause of death were higher in patients with presumed transmission via injection drug use than in other patients, with marked increases in rates of liver-related HR for injection drug use vs non—injection drug use, 6. Conclusions Important contributors to non-AIDS mortality in treated HIV-1—infected individuals must be addressed if decreases in mortality rates are to continue.

Combination antiretroviral therapy ART has dramatically improved life expectancy for human immunodeficiency virus type 1 HIV-1 —infected patients [ 1 ], primarily because of reductions in deaths attributable to AIDS-related conditions [ 2 ].

However, an increasing number of deaths are attributable to causes not conventionally considered to be HIV-1 related [ 3 ]. These may be related to immunodeficiency and inflammation attributable to uncontrolled viremia and, thus, may still be linked to HIV-1 infection [ 45 ].

Therefore, large clinical end point trials now incorporate non-AIDS events as end points [ 6 ]. With the introduction of more effective and tolerable ART regimens, it is important to monitor causes of death and assess associated risk factors.

Many AIDS-defining illnesses are poorly identified in the ICD, and some diseases eg, central nervous system diseases have a different etiology in HIV-1—infected patients and are, therefore, not covered or are at risk of misclassification.

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We hypothesized that associations of patient characteristics with overall mortality may mask differential associations with specific causes of death. Using data on antiretroviral-naive individuals starting ART from a collaboration of HIV-1 cohorts in high-income countries, we classified reported deaths using a system designed for attribution of causes of death in HIV-1—infected persons.

We described frequencies of specific causes of death, examined associations with prognostic factors at start of ART, and investigated whether causes of death differ between early and more recent ART eras and according to duration of time receiving treatment.

The collaboration is described in detail elsewhere [ 9 — 11 ] http: The dataset was assembled during and includes patients starting ART during — from 13 cohorts Appendix, which appears only on the online version of the journal.

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All cohorts had systematic though different approaches to capturing information regarding deaths, predominantly using linkages to death registries or hospital records.

At all sites, institutional review boards approved data collection. All cohorts provided anonymized data on a predefined set of demographic, laboratory, and clinical variables, which were pooled and analyzed centrally.

Coding cause of death We initially classified deaths into the 30 categories specified in the Cause of Death CoDe project protocol http: We produced summary tables with information on each death that included ICD-9, ICD, or free text coding of deaths; patient characteristics at ART initiation age, sex, pre-existing AIDS-defining conditions, risk transmission group ; details and timing of new AIDS events during receipt of treatment; time from treatment initiation to death; CD4 count obtained closest to death; and whether patients were receiving ART at time of death.

Deaths attributed to unspecified liver failure were classified as hepatitis CoDe 03 if the patient was positive for hepatitis C antibody at baseline or if hepatitis C status was unknown but HIV-1 transmission was through injection drug use.

An analysis of the hiv virus and the causes for aids

If the patient was not known to be an injection drug user or hepatitis C positive, then such deaths were coded as liver failure CoDe Deaths described as due to cardiac arrest or respiratory failure with no other information were coded as unknown CoDe Deaths with insufficient information to achieve a consensus were coded as cause unknown CoDe Hazard ratios HRs for death attributed to all and specific causes were estimated using multivariable Cox models.

In models for specific causes, patients who died of other causes were censored at date of death. All HRs were adjusted for these characteristics as well as year of ART initiation and were stratified by cohort.

Linearity of relationships of cause-specific log hazards with age and CD4 count were assessed using categories of these variables and fractional polynomials [ 15 ].

All subsequent analyses assumed that the effect of risk factors was the same across cohorts. We estimated cumulative incidence functions for AIDS-related, non—AIDS-related, and unknown deaths with use of nonparametric modelling that accounts for censoring because of competing causes of death [ 16 ].

These were stacked to illustrate the contribution of each to total mortality. Table 1 shows patient characteristics at baseline with corresponding years of follow-up and numbers of deaths.Acquired immunodeficiency syndrome (AIDS) is a chronic, potentially life-threatening condition caused by the human immunodeficiency virus (HIV).

By damaging your immune system, HIV interferes with your body's ability to fight the organisms that cause disease. AIDS is caused by the human immunodeficiency virus (HIV).

By leading to the destruction and/or functional impairment of cells of the immune system, notably CD4+ T cells, HIV progressively destroys the body's ability to fight infections and certain cancers.

AIDS Definition Acquired immune deficiency syndrome (AIDS) is an infectious disease caused by the human immunodeficiency virus (HIV).

An analysis of the hiv virus and the causes for aids

There are two variants of the HIV virus, HIV-1 and HIV-2, both of which ultimately cause AIDS. Scientists identified a type of chimpanzee in West Africa as the source of HIV infection in humans.

They believe that the chimpanzee version of the immunodeficiency virus (called simian immunodeficiency virus or SIV) most likely was transmitted to humans and mutated into HIV when humans hunted these chimpanzees for meat and came into contact with their infected blood.

Immune Deficiency); however, scientists later found evidence that the disease existed in the world for some years prior, i.e., subsequent analysis of a blood sample of a Bantu man, who died of an unidentified illness in the Belgian Congo in , made him the first confirmed case of an HIV infection.

HIV stands for Human Immunodeficiency is the virus that causes AIDS. AIDS stands for Acquired Immune Deficiency can be transmitted through the blood, sexual fluids, or breast milk of an HIV-infected person.

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